Diospolis ('City of Zeus') may refer to:

Asia

• Diospolis (Bithynia), in Bithynia, Anatolia
• Diospolis (Lydia), in Lydia, Anatolia
• Diospolis (Pontus), in Pontus, Anatolia
• Diospolis, later Byzantine Lydda, now Lod in modern Israel
  • Synod of Diospolis in above Lydda
• The first known name of Laodicea on the Lycus in Phrygia, Anatolia

Egypt

• Diospolis Magna (Great Zeus-City), the Greco-Roman name of Pharaonic Thebes
• Diospolis Parva (Little Zeus-City) or Diospolis Superior, the Greco-Roman names of Pharaonic Hiw
• Dispolis Inferior (Lower Zeus-City), the Greco-Roman name of Pharaonic Paiuenamun

Europe

• Diospolis in Thracia, a city and bishopric in Thrace, now in Bulgaria