David Hughes may refer to:
Arts
- Dave Hughes (born 1970), Australian comedian
- Dave Hughes (producer), American television producer and editor
- David Hughes (illustrator), British illustrator
- David Hughes (Emmerdale), fictional character in the ITV soap opera Emmerdale
Literature
- David Hughes (Eos Iâl) (1794–1862), Welsh poet and publisher
- David Hughes (illustrator), English artist and illustrator
- David Hughes (novelist) (1930–2005), British novelist
Music
- Dave Hughes (musician) (born 1981), American musician
- David Hughes (bass player) (born 1971), Swedish musician
- David Hughes (musician) (born 1960), English keyboardist
- David Hughes (tenor) (1925–1972), English singer
Science
- David Hughes (astronomer) (1941–2022), English astronomer specialising in comets
- 4205 David Hughes, an asteroid
- David Edward Hughes (1831–1900), British-born inventor, known for the microphone, and later, American academic
Sports
Cricket
- David Hughes (Hertfordshire cricketer) (born 1978), Irish cricketer
- David Hughes (Lancashire cricketer) (born 1947), English cricketer
- David Hughes (Somerset cricketer) (born 1934), English cricketer
Football
- David Hughes (American football) (born 1959), American football player
- David Hughes (footballer, born 1943), English footballer
- Dave Hughes (footballer) (born 1945), Australian rules footballer
- David Hughes (footballer, born 1958) (1958–2023), English footballer
- David Hughes (footballer, born 1972), Welsh footballer
- David Hughes (footballer, born 1978), Welsh footballer
Other sports
- David Hughes (hurler) (born 1967), Irish hurler
- David Hughes (sailor) (born 1978), American sailor
Other persons
- David Hughes (English academic) (1753/1754–1817), principal of Jesus College, Oxford
- David Hughes (priest) (1785–1850), Welsh Anglican priest
- David Hughes (RAF officer) (1899–?), First World War flying ace
- David Hughes (railroad executive), interim president and CEO of Amtrak, 2005–2006
See also
- Ysgol David Hughes, a school in Wales named after a local philanthropist
- Hughes (surname)
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