DDS may refer to:
Arts and media
- Digimon Data Squad, season 5 of the anime Digimon
 - Shin Megami Tensei: Digital Devil Saga, a 2004 video game spun off from the Shin Megami Tensei series
 - Dmitri Dmitriyevich Shostakovich, Russian composer
 - Death's Dynamic Shroud, American electronic and vaporwave trio
 
Organizations
Government agencies
- Disability Determination Service, a state agency in the United States that determines eligibility for federal disability benefits
 - Department of Driver Services, also known as Department of Motor Vehicles
 
Private organizations
- Davao Death Squad, a vigilante group in Davao City, Philippines
 - Davidson Day School, a pre-K–12 school in Davidson, North Carolina, United States
 - De Danske Skytteforeninger, a Danish sports organization
 - Diehard Duterte Supporters, supporters of Rodrigo Duterte, 16th president of the Philippines
 - Donovan Data Systems, a software and computer services company
 - Dutchess Day School, private pre-K through 8th grade school in Millbrook, New York, United States
 
Science and technology
Chemistry
- Dimethyldichlorosilane, an organosilicon compound
 - Dammarenediol II synthase, an enzyme
 
Computing and information technology
- Data Design System, a CAD software system
 - Direct Digital Synthesis / Direct digital synthesizer, a method for generation of periodic digital signals and used for creating arbitrary waveforms from a reference clock
 - Data Definition Specification, in software data management
 - Data Description Specifications, in AS/400 programming
 - Data Distribution Service, an Object Management Group standard for publish/subscribe middleware for distributed systems
 - Data dictionary system of ICL's VME operating system; see ICL VME#QuickBuild
 - Dataphone Digital Service or Digital Data System, types of leased line
 - Digital Data Storage, a storage tape format related to Digital Audio Tape (DAT)
 - Dimensional Data Storage
 - DirectDraw Surface, .dds texture files
 - Dynamic digital signage
 
Medicine
- Dapsone, also known as diaminodiphenyl sulfone (DDS), an antibiotic commonly used for the treatment of leprosy
 - Doctor of Dental Surgery, an academic degree
 - Dopamine dysregulation syndrome, a condition connected with treatment for Parkinson's disease
 - Drug delivery systems, how drugs are delivered to relevant areas or tissues
 
Other uses in science and technology
- Dark dune spot, a feature of the Martian landscape
 - Deflation Detection System, on motor vehicle tires
 - Dry deck shelter, a module that allows divers easy exit and entrance while a submarine is submerged
 
Other uses
- Dewey Decimal Classification, often called the Dewey Decimal System
 - Direct Delivery Scheme, of the Society of Independent Brewers
 
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