Co-pilot refers to the first officer (civil aviation), also known as the second pilot (sometimes referred to as the "co-pilot") of an aircraft.

Co-pilot or copilot may also refer to:

• "Co-Pilot" (song), song by Kristina Maria featuring Laza Morgan and Corneille
• Co-pilot Glacier, a short, steep tributary glacier, flowing from the slopes of Mount Overlord to the upper part of Aviator Glacier in Victoria Land, New Zealand
• Newark Co-Pilots, earlier minor league baseball team based in Newark, New York
• Performance Co-Pilot, also known as PCP, an open source tool for monitoring computer networks
• GitHub Copilot, an artificial intelligence tool for programming assistance
• Microsoft 365 Copilot, an artificial intelligence tool in Microsoft 365