Clerke may refer to:
People
- Agnes Mary Clerke (1842–1907), Irish astronomer and science writer
 - Charles Clerke (1741–1779), British naval officer and explorer
 - Charles Clerke (footballer) (1857–1944), English footballer
 - Ellen Mary Clerke (1840–1906), Irish poet, linguist and journalist
 - Francis Clerke (disambiguation)
 - John Clerke (disambiguation)
 - Clerke baronets, three baronetcies
- Sir Clement Clerke, 1st Baronet (died 1693), English entrepreneur
 - Sir William Clerke, 8th Baronet (1751–1818), English clergyman
 
 
Other
- .38/.45 Clerke, a wildcat semi-automatic pistol cartridge
 - Clerke (crater), a lunar crater named after Agnes Mary Clerke
 - Clerke Rocks, a group of small rocky islands in the South Atlantic, named after Charles Clerke
 - Clerke v. Harwood (1797), a United States Supreme Court case concerning debts owed to British subjects
 
See also
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