Cayo or cayó may refer to:
- Cayo (film), a 2005 Puerto Rican film starring Roselyn Sánchez
 - Cayo District, a district in the west of the nation of Belize
- San Ignacio, Belize, a town in the Cayo District (originally named "El Cayo")
 
 - Caio, Carmarthenshire, a village in Wales sometimes spelt with a 'y'
- Cayo Hundred, a geographic division named after the village
 
 - "Cayó", a 2022 song by Arca
 - Elsa Cayo (born 1951), Peruvian filmmaker
 
See also
- Caio (disambiguation)
 - Cay (sand island)
 
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