Caine may refer to:
People
- Caine (surname), a name (including a list of people with the surname)
 
Fictional entities
- Caine, a character from the animated series The Amazing Digital Circus
 - Caine Soren, a character in the novel series Gone by Michael Grant
 - Caine, an alternate spelling of the biblical Cain, and mythical first Vampire in the World of Darkness fictional universe
 - Caine, the antihero of the Heroes Die novel written by Matthew Stover
 - Caine the Longshot, a character in the manga and anime series Trigun
 - Caine, one of Corwin's brothers in The Chronicles of Amber series of fantasy novels
 - Horatio Caine, from the CSI: Miami television series
 - Kwai Chang Caine, a Shaolin monk from the Kung Fu television series
 - Caine "Kaydee" Lawson, the main character in Menace II Society film
 - Solomon Caine, a character in the Driver video game franchise
 - U.S.S. Caine, fictional ship of The Caine Mutiny franchise
 
Places
Other uses
- Caine Prize, for African Writing
 - CAINE Linux, a digital forensics Linux distribution
 
See also
- Cane (disambiguation)
 - Cain (disambiguation)
 - Kaine (surname)
 - Kaine (disambiguation)
 - Kain (disambiguation)
 - Kane (disambiguation)
 
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