The alphanumeric designation CA-12, CA 12 or CA12 may refer to:
- CA12, the carbonic anhydrase 12 enzyme and the gene that encodes it
- California's 12th congressional district
- California State Route 12, a highway in California
- CAC Boomerang, a WWII fighter aircraft manufactured by the Commonwealth Aircraft Corporation in Australia
- Comp Air 12, a civil utility aircraft manufactured by Comp Air Inc. in the USA
- USS North Carolina (ACR-12), an early 20th-century U.S. Navy armoured cruiser, later renamed USS Charlotte (CA-12)
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