Biodome may refer to:
- a closed ecological system
 - Bio-Dome, a 1996 movie starring Pauly Shore and Stephen Baldwin and directed by Jason Bloom.
 - the Montreal Biodome, a facility located in Montreal that allows visitors to walk through replicas of four ecosystems found in the Americas.
 - the Montreal Biosphère, a geodesic dome on Ile Sainte-Hélène in Montreal, Quebec, Canada used as the pavilion for the 1967 World Exhibition Expo 67.
 - Biosphere 2, an artificial closed ecosystem in Oracle, Arizona.
 - BIOS-3, a closed ecosystem at the Institute of Biophysics in Krasnoyarsk, Siberia.
 
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