Arachne is a figure in Greek mythology. It may also refer to:
- Arachne (Internet suite)
 - Arachne (archaeological database)
 - 407 Arachne, an asteroid
 - Julia Carpenter, a fictional superheroine also called Arachne
 - A group of characters in Sonic the Hedgehog (comic series)
 - A character in Soul Eater, a manga series
 - Sarah Hayes (crossword compiler), who uses the pseudonym Arachne.
 
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