Akindele is a surname of Yoruba origin meaning "conquering warrior returns home". Notable people with the surname include:
- Deji Akindele (born 1983), Nigerian basketball player
 - Funke Akindele (born 1976), Nigerian actress
 - Chief Labode Onadimaki Akindele, a Nigerian businessman, who was sued by the liquidators of BCCI in Bank of Credit and Commerce International (Overseas) Ltd v Akindele
 - Tesho Akindele (born 1992), Canadian soccer player
 
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