ALS (Amyotrophic Lateral Sclerosis) is a chronic and fatal form of motor neuron disease; also known as Lou Gehrig's disease.
ALS or Als may also refer to:
Places
- Als (island), Denmark
 
Aviation
- Airman Leadership School, a U.S. Air Force program
 - ALS – Aircraft Leasing Services, a Kenyan airline
 - Approach lighting system, an airport runway lighting system
 - San Luis Valley Regional Airport, IATA code ALS
 
Medicine
- Advanced life support, a level of medical training
 - Anterolateral system, part of the nervous system
 - Antibodies from lymphocyte secretions, an immunological assay
 - Angular leaf spot, a bacterial plant disease
 
Science and technology
- Acetolactate synthase, an enzyme
 - Advanced Light Source, a synchrotron radiation facility
 - ALSN, automatic train signalling (автоматична локомотивна сигналізація), a train protection system
 - Alternate line service, a mobile phone feature
 - Aluminized steel, as used in engineering drawings
 - Ammonium lauryl sulfate, a household chemical
 - Antilag system, a system used on turbocharged engines
 - Audio Lossless Coding, an audio codec
 - LS TTL, advanced low-power Schottky
 - Photodetector, ambient light sensor
 - Alternating least squares, a matrix factorization method
 
Organizations
- Als, a nickname used for the Montreal Alouettes of the Canadian Football League
 - ALS Association, an American nonprofit organization
 - American Littoral Society, an American environmental organization
 - Arrowhead Library System (Wisconsin)
 - Australian Linguistic Society
 - Associated London Scripts, a comedy-writers collective founded by Spike Milligan
 
Other uses
- A. Lange & Söhne, a German luxury watch brand
 - als, since 2003 prefix for the Wikipedia (als:Wikipedia:Houptsyte) of Alemannic German dialects like Alsatian, Swabian, Swiss German
 - als, since 2007 the ISO 639-3 code for the southern Albanian dialect (Tosk Albanian)
 - Alternative Learning System (Philippines), a modular non-formal education program
 - Associate of the Linnean Society of London
 - Auld Lang Syne, a traditional Scottish folk song
 - Autographed Letter Signed, a term used by autograph collectors
 - Singapore Area Licensing Scheme
 
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