546 may refer to:

• the year 546 AD

Any of the following American roads:

• KY 546, a former state highway in Kentucky
• LA 546, a state highway in Louisiana
• Route 546, a state highway in Maryland
• CR546, a county route in the state of New Jersey
• Erie County Route 546, a county route in the state of New York
• Route 546, a state highway in Ohio
• Route 546, a state highway in Pennsylvania
• Route 546, a state highway in Washington

Or, Secondary Highway 546 in the Algoma District of Ontario, Canada.