The number 488 may refer to any of several things:

• The year 488.
• The year 488 BC
• British Rail Class 488, unpowered electric multiple unit trailer sets, converted from Mark 2F coaches
• Ferrari 488, a mid-engined sports car
• IEEE-488, a short-range, digital communications bus specification
• 488 Kreusa, a minor planet orbiting the Sun
• Nevada State Route 488
• New York State Route 488
• No. 488 Squadron RNZAF
• Unterseeboot 488 (U-488), a Type XIV U-boat ("Milchkuh") of the Kriegsmarine
• USS McCalla (DD-488), a Gleaves-class destroyer
• USS Sarda (SS-488), a Tench-class submarine